4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride

Base Information

Chemical Name:4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride
CAS No.:1393368-52-9
Molecular Formula:C₁₄H₁₆F₃NO₂*ClH
Molecular Weight:323.743
Hs Code.:

Synonyms:4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride

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Chemical Property of 4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride

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Technology Process of 4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride

There total 10 articles about 4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1204331-48-5
4-(4-methoxycarbonyl-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

: 1393368-52-9
4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; for 16h;
DOI:10.1021/jm300601d

Reference yield: 88.0%

: 67-56-1
methanol

: 1204331-27-0
4-(4-carboxy-2-trifluoromethylphenyl)piperidine-1-carboxylic acid tert-butyl ester

: 1393368-52-9
4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; at 20 ℃;

Reference yield:

: 1204331-26-9
4-(4-methoxycarbonyl-2-trifluoromethylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1393368-52-9
4-piperidin-4-yl-3-trifluoromethyl-benzoic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; acetic acid; platinum(IV) oxide / 60 h / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane; dichloromethane / 16 h

With hydrogenchloride; platinum(IV) oxide; hydrogen; acetic acid; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm300601d