3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester

Base Information

• Chemical Name: 3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester
• CAS No.: 219653-33-5
• Molecular Formula: C₃₄H₃₂N₂O₅
• Molecular Weight: 548.638

Synonyms:3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester

Chemical Property of 3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester

Chemical Property:

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Technology Process of 3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester

There total 3 articles about 3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon monoxide (201230-82-2) + 3-{4-[2-(benzooxazol-2-yl-methyl-amino)-ethoxy]-phenyl}-2-(2-iodo-benzyl)-propionic acid methyl ester (1026482-37-0) + phenylboronic acid (98-80-6) → 3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester (219653-33-5)

Guidance literature:

With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 95 ℃; for 22h; under 760 Torr;

DOI:10.1021/jm9804127

Reference yield:

2-Iodobenzyl bromide (40400-13-3) → 3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester (219653-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hexamethyldisilazide / 1.) THF, -78 deg C, 90 min, 2.) THF, -78 deg C, 90 min

2: 144 mg / K₂CO₃ / PdCl₂(PPh₃)2 / dioxane / 22 h / 95 °C / 760 Torr

With sodium hexamethyldisilazane; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane;

DOI:10.1021/jm9804127

Reference yield:

3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>propionic acid methyl ester (153939-49-2) → 3-<4-<2-(benzoxazol-2-ylmethylamino)ethoxy>phenyl>-2-<(2-benzoylphenyl)methyl>propionic acid methyl ester (219653-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium hexamethyldisilazide / 1.) THF, -78 deg C, 90 min, 2.) THF, -78 deg C, 90 min

2: 144 mg / K₂CO₃ / PdCl₂(PPh₃)2 / dioxane / 22 h / 95 °C / 760 Torr

With sodium hexamethyldisilazane; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane;

DOI:10.1021/jm9804127

upstream raw materials:

carbon monoxide

3-{4-[2-(benzooxazol-2-yl-methyl-amino)-ethoxy]-phenyl}-2-(2-iodo-benzyl)-propionic acid methyl ester

phenylboronic acid

2-Iodobenzyl bromide

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