6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole
• CAS No.: 1241537-79-0
• Molecular Formula: C₂₄H₃₄N₆S
• Molecular Weight: 438.64

Synonyms:6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property of 6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property:

• Density: 1.28±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

E260 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole

There total 5 articles about 6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-[(4-methyl-1-piperazinyl)methyl]piperidine (735262-46-1) + 2-bromo-6-(4-isopropylphenyl)imidazo[2,1-b][1,3,4]thiadiazole (1097016-59-5) → 6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole (1241537-79-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 85 ℃;

DOI:10.1038/s41467-017-00832-w

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → 6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole (1241537-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / chloroform / 1 h / 20 °C

1.2: 2 h / Reflux

2.1: hydrogenchloride / ethanol; water / 2 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 85 °C

With hydrogenchloride; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; chloroform; water; isopropyl alcohol;

DOI:10.1038/s41467-017-00832-w

Reference yield:

1-methyl-piperazine (109-01-3) → 6-(4-isopropylphenyl)-2-{4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl}imidazo[2,1-b][1,3,4]thiadiazole (1241537-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / chloroform / 1 h / 20 °C

1.2: 2 h / Reflux

2.1: hydrogenchloride / ethanol; water / 2 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 85 °C

With hydrogenchloride; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; chloroform; water; isopropyl alcohol;

DOI:10.1038/s41467-017-00832-w

upstream raw materials:

4-[(4-methyl-1-piperazinyl)methyl]piperidine

2-bromo-6-(4-isopropylphenyl)imidazo[2,1-b][1,3,4]thiadiazole

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

1-methyl-piperazine

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