6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol

Base Information

Chemical Name:6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol
CAS No.:53905-57-0
Molecular Formula:C₁₇H₁₇NO₄
Molecular Weight:299.326
Hs Code.:

Synonyms:6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol

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Chemical Property of 6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol

Chemical Property:

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Technology Process of 6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol

There total 3 articles about 6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 4747-99-3
Norlaudanosolin

: 53905-57-0
6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol

: 53905-56-9
6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,10,11-tetraol

Guidance literature:: With potassium phosphate; In water; acetonitrile; at 40 ℃; for 0.5h; pH=6;
DOI:10.1039/c4gc02325k

Reference yield:

: 10597-60-1
hydroxytyrosol

: 53905-57-0
6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol

: 53905-56-9
6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,10,11-tetraol

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide; dichloromethane / 1 h / -15 °C

2: potassium phosphate / water; acetonitrile / 12 h / 50 °C / pH 6

3: potassium phosphate / water; acetonitrile / 0.5 h / 40 °C / pH 6

With potassium phosphate; sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; dimethyl sulfoxide; acetonitrile; 1: |Parikh-Doering Oxidation / 2: |Pictet-Spengler Synthesis / 3: |Pictet-Spengler Synthesis;
DOI:10.1039/c4gc02325k

Reference yield:

: 5707-55-1
3,4-Dihydroxyphenylacetaldehyde

: 53905-57-0
6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,9,10-tetraol

: 53905-56-9
6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,3,10,11-tetraol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / water; acetonitrile / 12 h / 50 °C / pH 6

2: potassium phosphate / water; acetonitrile / 0.5 h / 40 °C / pH 6

With potassium phosphate; In water; acetonitrile; 1: |Pictet-Spengler Synthesis / 2: |Pictet-Spengler Synthesis;
DOI:10.1039/c4gc02325k