Technology Process of (2S,3S,4S,5R)-2-benzyloxy-4-methyl-7-octen-3,5-diol
There total 3 articles about (2S,3S,4S,5R)-2-benzyloxy-4-methyl-7-octen-3,5-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
acetic acid; tetramethylammonium triacetoxyborohydride;
In
acetonitrile;
at -35 - 0 ℃;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol202210k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C / Inert atmosphere
2.1: acetic acid; tetramethylammonium triacetoxyborohydride / acetonitrile / -35 - 0 °C / Inert atmosphere
With
titanium tetrachloride; acetic acid; N-ethyl-N,N-diisopropylamine; tetramethylammonium triacetoxyborohydride;
In
dichloromethane; acetonitrile;
DOI:10.1021/ol202210k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 0 °C
2.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 °C
3.1: tetramethylammonium triacetoxyborohydride; acetic acid / acetonitrile / -35 °C / Inert atmosphere
With
titanium tetrachloride; acetic acid; N-ethyl-N,N-diisopropylamine; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1039/c7ob00072c
