4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile

Base Information

Chemical Name:4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile
CAS No.:1334320-47-6
Molecular Formula:C₁₈H₁₂F₂N₄O
Molecular Weight:338.316
Hs Code.:

Synonyms:4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile

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Chemical Property of 4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile

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Technology Process of 4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile

There total 5 articles about 4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1330145-03-3
C₁₈H₁₀F₂N₄O

: 1334320-47-6
4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile

Guidance literature:: With potassium borohydride; In methanol; at 0 - 5 ℃; for 2h;
DOI:10.1016/j.bmc.2011.07.023

Reference yield:

: 4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile

: 1334320-47-6
4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 0.5 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / -20 - 20 °C / Inert atmosphere

3: oxygen; sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

4: potassium borohydride / methanol / 2 h / 0 - 5 °C

With potassium borohydride; oxygen; sodium hydride; trichlorophosphate; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.07.023

Reference yield:

: 1334320-24-9
C₁₉H₁₁F₂N₅

: 1334320-47-6
4-((4-((2,5-difluorophenyl)(hydroxy)methyl)pyrimidin-2-yl)amino)-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: oxygen; sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

2: potassium borohydride / methanol / 2 h / 0 - 5 °C

With potassium borohydride; oxygen; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2011.07.023