ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate

Base Information

Chemical Name:ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate
CAS No.:1240361-24-3
Molecular Formula:C₂₉H₃₉N₃O₆S
Molecular Weight:557.711
Hs Code.:

Synonyms:ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate

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Chemical Property of ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate

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Technology Process of ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate

There total 5 articles about ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 924-44-7
glyoxylic acid ethyl ester

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 923010-21-3
2-(Boc-amino)-5-phenylthiophene-3-carboxylic acid

: 2516-47-4
cyclopropanemethylamine

: 1240361-24-3
ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate

Guidance literature:: In methanol; at 20 ℃; for 48h;
DOI:10.1111/j.1747-0285.2010.00989.x

Reference yield:

: 923010-20-2
methyl 2-[(tert-butoxycarbonyl)amino]-5-phenylthiophene-3-carboxylate

: 1240361-24-3
ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol; water / 1 h / Reflux

1.2: pH 6

2.1: methanol / 48 h / 20 °C

With potassium hydroxide; In methanol; ethanol; water; 2.1: Ugi condensation;
DOI:10.1111/j.1747-0285.2010.00989.x

Reference yield:

: 61325-02-8
2-amino-5-phenylthiophene-3-carboxylic acid methyl ester

: 1240361-24-3
ethyl 2-[({2-[(tert-butoxycarbonyl)amino]-5-phenylthien-3-yl}carbonyl)(cyclopropylmethyl)amino]-3-(tert-butylamino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / tetrahydrofuran / Reflux

2.1: potassium hydroxide / ethanol; water / 1 h / Reflux

2.2: pH 6

3.1: methanol / 48 h / 20 °C

With dmap; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; water; 3.1: Ugi condensation;
DOI:10.1111/j.1747-0285.2010.00989.x