(5S,8S)-methyl 8-benzyl-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-13-thia-4,7,10-triazapentadecan-15-oate

Base Information

• Chemical Name: (5S,8S)-methyl 8-benzyl-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-13-thia-4,7,10-triazapentadecan-15-oate
• CAS No.: 1384584-06-8
• Molecular Formula: C₂₅H₂₉N₃O₇S
• Molecular Weight: 515.587

Synonyms:(5S,8S)-methyl 8-benzyl-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-13-thia-4,7,10-triazapentadecan-15-oate

Chemical Property of (5S,8S)-methyl 8-benzyl-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-13-thia-4,7,10-triazapentadecan-15-oate

Chemical Property:

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Technology Process of (5S,8S)-methyl 8-benzyl-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-13-thia-4,7,10-triazapentadecan-15-oate

There total 2 articles about (5S,8S)-methyl 8-benzyl-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-13-thia-4,7,10-triazapentadecan-15-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

benzyl ((S)-1-(((S)-1-((2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamate (1342794-05-1) + Methyl thioglycolate (2365-48-2) → (5S,8S)-methyl 8-benzyl-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-13-thia-4,7,10-triazapentadecan-15-oate (1384584-06-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1111/j.1747-0285.2012.01364.x

Reference yield:

(5S,8S)-8-benzyl-5-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid (16814-50-9,116460-40-3) → (5S,8S)-methyl 8-benzyl-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-13-thia-4,7,10-triazapentadecan-15-oate (1384584-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / -45 °C

2: triethylamine / tetrahydrofuran / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1111/j.1747-0285.2012.01364.x

upstream raw materials:

benzyl ((S)-1-(((S)-1-((2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamate

Methyl thioglycolate

(5S,8S)-8-benzyl-5-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid

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