isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate

Base Information

• Chemical Name: isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate
• CAS No.: 1426449-67-3
• Molecular Formula: C₂₃H₂₃N₅O₄
• Molecular Weight: 433.467
• Mol file: 1426449-67-3.mol

Synonyms:isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate

Chemical Property of isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate

There total 6 articles about isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate (1426671-54-6) + ethylmagnesium bromide (925-90-6) → N-(5-{5-[2-(1-hydroxycyclopropyl)ethyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide (1426448-46-5) + isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate (1426449-67-3)

Guidance literature:

In tetrahydrofuran; at -15 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

titanium(IV) isopropylate (546-68-9) + methyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate (1426671-54-6) + ethylmagnesium bromide (925-90-6) → N-(5-{5-[2-(1-hydroxycyclopropyl)ethyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide (1426448-46-5) + isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate (1426449-67-3)

Guidance literature:

In tetrahydrofuran; at -15 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

N-(5-cyano-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide (1426135-64-9) → N-(5-{5-[2-(1-hydroxycyclopropyl)ethyl]-1,2,4-oxadiazol-3-yl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide (1426448-46-5) + isopropyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate (1426449-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydroxylamine / ethanol; water / 4 h / 20 - 50 °C

2.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 0.03 h

2.2: 0.5 h / 125 °C / Microwave irradiation

3.1: tetrahydrofuran / 16 h / -15 - 20 °C / Inert atmosphere

With hydroxylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; water;

upstream raw materials:

titanium(IV) isopropylate

methyl 3-(3-(3-(imidazo[1,2-a]pyridine-3-carboxamido)-4-methylphenyl)-1,2,4-oxadiazol-5-yl)propanoate

ethylmagnesium bromide

N-(5-cyano-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide