Technology Process of 7,16-bis<4-<1-(3,5-dimethoxycarbonyl)phenyl-4,5-dihydro-1H-pyrazol-3-yl>phenyl>-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane
There total 7 articles about 7,16-bis<4-<1-(3,5-dimethoxycarbonyl)phenyl-4,5-dihydro-1H-pyrazol-3-yl>phenyl>-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1: 28 percent / tetrabutylammonium fluoride trihydrate / 12 h / 150 °C
2: 1.) LDA / 1) THF, heptane, -78 deg C, 1 h; 2) THF, heptane, 0 deg C, 2 h
3: 75 percent / NaHCO3, NaIO4 / tetrahydrofuran; methanol; H2O / 0.5 h / Ambient temperature
4: 52 percent / acetic acid / 264 h / Ambient temperature; further reagent and conditions
With
sodium periodate; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1016/S0040-4020(99)00167-2
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) sodium nitrite, aq. HCl, 2.) sodium sulphite, 3.) conc. HCl / 1) water, 0-5 deg C, 1 h; 2) water, 50-60 deg C, 45 min; 3) water, 90 deg C, 1 hi930
2: H2SO4 / 2 h / Heating
3: 52 percent / acetic acid / 264 h / Ambient temperature; further reagent and conditions
With
hydrogenchloride; sulfuric acid; sodium sulfite; sodium nitrite;
In
acetic acid;
DOI:10.1016/S0040-4020(99)00167-2
