(4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene

Base Information

Chemical Name:(4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene
CAS No.:537036-48-9
Molecular Formula:C₃₁H₄₆O₅Si
Molecular Weight:526.789
Hs Code.:

Synonyms:(4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene

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Chemical Property of (4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene

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Technology Process of (4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene

There total 6 articles about (4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 100-39-0
benzyl bromide

: 537036-47-8
(4aS,6R,7S,8aR)-6-(2-Benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalen-7-ol

: 537036-48-9
(4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 ℃; for 0.5h;
DOI:10.1021/jo035145d

Reference yield:

: 254442-52-9
Trifluoro-methanesulfonic acid (4R,5S)-2,2-di-tert-butyl-5-triethylsilanyloxy-[1,3,2]dioxasilinan-4-ylmethyl ester

: 537036-48-9
(4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / n-BuLi / hexamethylphosphoric acid triamide; tetrahydrofuran; hexane / 0.5 h / -100 °C

2: 93 percent / TsOH*H₂O / CH₂Cl₂ / 23 h / 0 °C

3: 99 percent / NaBH₄ / methanol; CH₂Cl₂ / 1 h / -78 °C

4: 100 percent / KHMDS / tetrahydrofuran; toluene / 0.5 h / 0 °C

With sodium tetrahydroborate; n-butyllithium; potassium hexamethylsilazane; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; toluene;
DOI:10.1021/jo035145d

Reference yield:

: 537036-25-2
(4aS,6R,8aR)-6-(2-benzyloxyethyl)-2,2-di-tert-butyl-6-methyldecahydro-1,3,5-trioxa-2-silanaphthalen-7-one

: 537036-48-9
(4aS,6R,7S,8aR)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,2-di-tert-butyl-6-methyl-hexahydro-1,3,5-trioxa-2-sila-naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / NaBH₄ / methanol; CH₂Cl₂ / 1 h / -78 °C

2: 100 percent / KHMDS / tetrahydrofuran; toluene / 0.5 h / 0 °C

With sodium tetrahydroborate; potassium hexamethylsilazane; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo035145d