2-FLUORO-4-PHENYLPYRIDINE

Base Information

• Chemical Name: 2-FLUORO-4-PHENYLPYRIDINE
• CAS No.: 116241-62-4
• Molecular Formula: C11H8FN
• Molecular Weight: 173.19
• Mol file: 116241-62-4.mol

Synonyms:2-Fluoro-4-phenylpyridine;

Chemical Property of 2-FLUORO-4-PHENYLPYRIDINE

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 277.712 °C at 760 mmHg
• Flash Point: 121.756 °C
• PSA: 12.89000
• Density: 1.138 g/cm³
• LogP: 2.88770

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-4-phenylpyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-4-PHENYLPYRIDINE

There total 1 articles about 2-FLUORO-4-PHENYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-bromo-2-fluoropyridine (128071-98-7) + phenylboronic acid (98-80-6) → 2-fluoro-4-phenylpyridine (116241-62-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 80 ℃; for 2h;

Reference yield: 75.0%

2-fluoro-4-phenylpyridine (116241-62-4) + methyl iodide (74-88-4) → 2-fluoro-1-methyl-4-phenylpyridin-1-ium iodide

Guidance literature:

at 60 ℃; for 72h; Sealed tube;

Reference yield: 60.0%

(1E)-1-nitropent-1-ene (3156-72-7,66022-60-4) + 2-fluoro-4-phenylpyridine (116241-62-4) → 2-fluoro-3-(1-nitropentan-2-yl)-4-phenylpyridine

Guidance literature:

2-fluoro-4-phenylpyridine; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; Inert atmosphere;

(1E)-1-nitropent-1-ene; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02098

upstream raw materials:

4-bromo-2-fluoropyridine

phenylboronic acid

Refernces