(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 2-(3,4-dichlorophenyl)-6-(4-methoxyphenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Base Information

Chemical Name:(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 2-(3,4-dichlorophenyl)-6-(4-methoxyphenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate
CAS No.:1402852-71-4
Molecular Formula:C₂₈H₂₁Cl₂F₆NO₇
Molecular Weight:668.374
Hs Code.:

Synonyms:(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 2-(3,4-dichlorophenyl)-6-(4-methoxyphenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

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Chemical Property of (5S,6R,9S)-bis(2,2,2-trifluoroethyl) 2-(3,4-dichlorophenyl)-6-(4-methoxyphenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

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Technology Process of (5S,6R,9S)-bis(2,2,2-trifluoroethyl) 2-(3,4-dichlorophenyl)-6-(4-methoxyphenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

There total 2 articles about (5S,6R,9S)-bis(2,2,2-trifluoroethyl) 2-(3,4-dichlorophenyl)-6-(4-methoxyphenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1402852-65-6
(Z)-2-(3,4-dichlorophenyl)-4-(4-methoxybenzylidene)oxazol-5(4H)-one

: 104883-33-2
malonic acid di(2,2,2-trifluoroethyl ester)

: 1402852-71-4
(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 2-(3,4-dichlorophenyl)-6-(4-methoxyphenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Guidance literature:: With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 20 ℃; for 16.8333h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja309003x DOI:10.1021/ja309003x

Reference yield:

: 17321-80-1
2-(3,4-dichlorobenzamido)acetic acid

: 123-11-5
4-methoxy-benzaldehyde

: 1402852-71-4
(5S,6R,9S)-bis(2,2,2-trifluoroethyl) 2-(3,4-dichlorophenyl)-6-(4-methoxyphenyl)-4-oxo-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / acetic anhydride / 4 h / Inert atmosphere; Reflux

2: trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium(0) chloroform complex / toluene / 16.83 h / 20 °C / Inert atmosphere

With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium methylate; In acetic anhydride; toluene;
DOI:10.1021/ja309003x DOI:10.1021/ja309003x