benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate

Base Information

Chemical Name:benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate
CAS No.:1186400-73-6
Molecular Formula:C₁₈H₁₉NO₂S₂
Molecular Weight:345.486
Hs Code.:

Synonyms:benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate

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Chemical Property of benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate

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Technology Process of benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate

There total 3 articles about benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1186401-02-4
benzyl (2-((4-(methylthio)phenyl)thio)ethyl)carbamate

: 1186400-73-6
benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In benzene; at 80 ℃; for 14h;

Reference yield:

: 663623-51-6
2-(4-Methylsulfanyl-phenylsulfanyl)-ethylamine hydrochloride sait

: 1186400-73-6
benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 °C

1.2: 0 - 20 °C

2.1: toluene-4-sulfonic acid / toluene / 18 h / 70 °C

With toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene;
DOI:10.1021/acs.oprd.7b00260

Reference yield:

: 1122-97-0
4-methylsulfanyl-thiophenol

: 1186400-73-6
benzyl 7-(methylthio)-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 50 °C

2.1: triethylamine / dichloromethane / 0 °C

2.2: 0 - 20 °C

3.1: toluene-4-sulfonic acid / toluene / 18 h / 70 °C

With potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/acs.oprd.7b00260