1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine

Base Information

Chemical Name:1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine
CAS No.:149692-12-6
Molecular Formula:C₂₈H₂₉N₅O₃
Molecular Weight:483.57
Hs Code.:

Synonyms:1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine

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Chemical Property of 1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine

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Technology Process of 1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine

There total 9 articles about 1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14676-01-8
3-(tert-butoxycarbonylamino)-3-phenylpropanoic acid

: 149692-12-6
1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / HOBT, DCC / dimethylformamide / 18 h / Ambient temperature

2: 98 percent / 6.5 N aq. HCl / CHCl₃; dioxane / 1 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00072a019

Reference yield:

: 6959-47-3
2-chloromethylpyridine hydrochloride

: 149692-12-6
1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / H₂O / 18 h / Ambient temperature

2: 98 percent / 1.5 N aq. NaOH / tetrahydrofuran / 24 h / Ambient temperature

3: 92 percent / acetone / 48 h / Ambient temperature

4: 70 g / DBU / acetonitrile / 18 h / Ambient temperature

5: 99 percent / 6.5 N HCl / CHCl₃; dioxane / 1 h / Ambient temperature

6: 86 percent / HOBT, DCC / dimethylformamide / 18 h / Ambient temperature

7: 98 percent / 6.5 N aq. HCl / CHCl₃; dioxane / 1 h / Ambient temperature

8: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00072a019

Reference yield:

: 55579-01-6
1-(pyridine-2-ylmethyl)piperazine

: 149692-12-6
1-(3-((N-phenoxycarbonyl)amino)-3-phenylpropanoyl)-4-((2-methyl-3-pyridyl)cyanomethyl)piperazine

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / 1.5 N aq. NaOH / tetrahydrofuran / 24 h / Ambient temperature

2: 92 percent / acetone / 48 h / Ambient temperature

3: 70 g / DBU / acetonitrile / 18 h / Ambient temperature

4: 99 percent / 6.5 N HCl / CHCl₃; dioxane / 1 h / Ambient temperature

5: 86 percent / HOBT, DCC / dimethylformamide / 18 h / Ambient temperature

6: 98 percent / 6.5 N aq. HCl / CHCl₃; dioxane / 1 h / Ambient temperature

7: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00072a019