C₁₉H₁₉FN₄O₂

Base Information

Chemical Name:C₁₉H₁₉FN₄O₂
CAS No.:1192603-95-4
Molecular Formula:C₁₉H₁₉FN₄O₂
Molecular Weight:354.384
Hs Code.:

C<sub>19</sub>H<sub>19</sub>FN<sub>4</sub>O<sub>2</sub>

Synonyms:C₁₉H₁₉FN₄O₂

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Chemical Property of C₁₉H₁₉FN₄O₂

Chemical Property:

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Technology Process of C₁₉H₁₉FN₄O₂

There total 6 articles about C₁₉H₁₉FN₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1192603-94-3
5-[(2S,3R)-1-(4-cyano-3-fluorophenyl)-3-hydroxy-2-methylpyrrolidin-3-yl]pyridine-2-carboxylic acid

: 74-89-5
methylamine

: 1192603-95-4
C₁₉H₁₉FN₄O₂

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1016/j.bmc.2012.11.001

Reference yield:

: 151004-19-2
(4S,5S)-5-methyl-4-hydroxy-2-oxopyrrolidine

: 1192603-95-4
C₁₉H₁₉FN₄O₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium bis(2-methoxyethoxy)aluminum dihydride / toluene; tetrahydrofuran / 4 h / 0 - 70 °C

1.2: 20 °C

1.3: 18 h / 0 - 20 °C

2.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / acetonitrile / 20 h / 20 °C / Molecular sieve

3.1: n-butyllithium / hexane; diethyl ether / -78 - 20 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / 60 °C

5.1: hydrogen; 10 % palladium on carbon / methanol / 3 h / 20 °C

6.1: lithium carbonate / dimethyl sulfoxide / 2 h / 100 °C

7.1: sodium hydroxide; water / tetrahydrofuran; ethanol / 2 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran; N,N-dimethyl-formamide / 14 h / 20 °C

With 10 % palladium on carbon; n-butyllithium; tetrapropylammonium perruthennate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium bis(2-methoxyethoxy)aluminum dihydride; water; hydrogen; lithium carbonate; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2012.11.001

Reference yield:

: 1192609-30-5
methyl 5-{(2S,3R)-1-[(benzyloxy)carbonyl]-3-hydroxy-2-methylpyrrolidin-3-yl}pyridine-2-carboxylate

: 1192603-95-4
C₁₉H₁₉FN₄O₂

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; 10 % palladium on carbon / methanol / 3 h / 20 °C

2: lithium carbonate / dimethyl sulfoxide / 2 h / 100 °C

3: sodium hydroxide; water / tetrahydrofuran; ethanol / 2 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran; N,N-dimethyl-formamide / 14 h / 20 °C

With 10 % palladium on carbon; water; hydrogen; lithium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.001