2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide

Base Information

• Chemical Name: 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide
• CAS No.: 1416276-13-5
• Molecular Formula: C₂₄H₂₀ClN₃O₃S
• Molecular Weight: 465.96
• Mol file: 1416276-13-5.mol

Synonyms:2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide

Chemical Property of 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide

There total 3 articles about 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2,2'-dithiodibenzoyl bis-benzylalanine methyl ester (1416276-14-6) + 3-chlorobenzhydrazide (1673-47-8) → 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide (1416276-13-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2012.10.058

Reference yield:

2,2'-dithiobenzoic acid (119-80-2) → 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide (1416276-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.67 h / 20 °C / Reflux

2: triethylamine / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.10.058

Reference yield:

2,2'-dithiodibenzoyl bis-alanine methyl ester → 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide (1416276-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.10.058

upstream raw materials:

2,2'-dithiobenzoic acid

2,2'-dithiodibenzoyl bis-benzylalanine methyl ester

3-chlorobenzhydrazide