2,2'-dithiodibenzoyl bis-benzylalanine methyl ester

Base Information

• Chemical Name: 2,2'-dithiodibenzoyl bis-benzylalanine methyl ester
• CAS No.: 1416276-14-6
• Molecular Formula: C₃₆H₃₆N₂O₆S₂
• Molecular Weight: 656.824
• Mol file: 1416276-14-6.mol

Synonyms:2,2'-dithiodibenzoyl bis-benzylalanine methyl ester

Chemical Property of 2,2'-dithiodibenzoyl bis-benzylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-dithiodibenzoyl bis-benzylalanine methyl ester

There total 2 articles about 2,2'-dithiodibenzoyl bis-benzylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2'-dithiodibenzoyl bis-alanine methyl ester + D,L-homophenylalanine methyl ester (24469-05-4) → 2,2'-dithiodibenzoyl bis-benzylalanine methyl ester (1416276-14-6)

Guidance literature:

With triethylamine; at 20 ℃;

DOI:10.1016/j.bmc.2012.10.058

Reference yield:

2,2'-dithiobenzoic acid (119-80-2) → 2,2'-dithiodibenzoyl bis-benzylalanine methyl ester (1416276-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.67 h / 20 °C / Reflux

2: triethylamine / 20 °C

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.10.058

Reference yield: 90.0%

2,2'-dithiodibenzoyl bis-benzylalanine methyl ester (1416276-14-6) → methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acetate (1416276-17-9)

Guidance literature:

With bromine; triethylamine; In dichloromethane; for 0.583333h;

DOI:10.1016/j.bmc.2012.10.058

upstream raw materials:

2,2'-dithiobenzoic acid

D,L-homophenylalanine methyl ester

Downstream raw materials:

2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid 2-(3-fluorobenzoyl)hydrazide

methyl 2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acetate

2-(3-oxo-1,2-benzisothiazol-3(2H)-2-yl)-4-phenylbutanoic acid