(S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

Base Information

Chemical Name:(S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one
CAS No.:1043450-43-6
Molecular Formula:C₁₉H₂₆FNO₅
Molecular Weight:367.418
Hs Code.:

Synonyms:(S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

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Chemical Property of (S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

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Technology Process of (S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

There total 7 articles about (S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1043450-42-5
(S)-3-((R,Z)-6-(benzyloxy)-2-(4-fluoro-3-methylphenoxy)hex-4-enoyl)-4-isopropyloxazolidin-2-one

: 1043450-43-6
(S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h;

Reference yield:

: C₂₆H₃₀FNO₅

: 1043450-43-6
(S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: With palladium on carbon; hydrogen; In ethanol; at 20 ℃; under 760.051 Torr;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 1043450-40-3
2-(4-fluoro-3-methylphenoxy)acetyl chloride

: 1043450-43-6
(S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

1.2: 2 h / -70 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

2.2: 1 h / -70 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C

With n-butyllithium; hydrogen; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane;