(R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Base Information

Chemical Name:(R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide
CAS No.:1043450-46-9
Molecular Formula:C₂₁H₂₆F₂N₂O₃
Molecular Weight:392.446
Hs Code.:

Synonyms:(R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

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Technology Process of (R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

There total 10 articles about (R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1043450-45-8
(S)-3-((R)-6-(4-fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

: 1043450-46-9
(R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Guidance literature:: With potassium cyanide; hydroxylamine; In tetrahydrofuran; methanol; water; at 20 ℃;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 1043450-43-6
(S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

: 1043450-46-9
(R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 20 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

3: potassium cyanide; hydroxylamine / tetrahydrofuran; methanol; water / 20 °C

With potassium cyanide; hydroxylamine; sodium tris(acetoxy)borohydride; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 1043450-44-7
(R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

: 1043450-46-9
(R)-6-(4-Fluoro-3-methylbenzylamino)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

2: potassium cyanide; hydroxylamine / tetrahydrofuran; methanol; water / 20 °C

With potassium cyanide; hydroxylamine; sodium tris(acetoxy)borohydride; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.02.010