(R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

Base Information

Chemical Name:(R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal
CAS No.:1043450-44-7
Molecular Formula:C₁₉H₂₄FNO₅
Molecular Weight:365.402
Hs Code.:

Synonyms:(R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

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Chemical Property of (R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

Chemical Property:

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Technology Process of (R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

There total 8 articles about (R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1043450-43-6
(S)-3-((R)-2-(4-fluoro-3-methylphenoxy)-6-hydroxyhexanoyl)-4-isopropyloxazolidin-2-one

: 1043450-44-7
(R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 1043450-39-0
ethyl 2-(4-fluoro-3-methylphenoxy)acetate

: 1043450-44-7
(R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide; water / 1,4-dioxane / 0.5 h / 20 - 25 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

3.2: 2 h / -70 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

4.2: 1 h / -70 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C

6.1: Dess-Martin periodane / dichloromethane / 3 h / 25 °C

With potassium hydroxide; n-butyllithium; oxalyl dichloride; water; hydrogen; Dess-Martin periodane; lithium hexamethyldisilazane; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane;

Reference yield:

: 1043450-40-3
2-(4-fluoro-3-methylphenoxy)acetyl chloride

: 1043450-44-7
(R)-5-(4-fluoro-3-methylphenoxy)-6-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-6-oxohexanal

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

1.2: 2 h / -70 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -70 °C

2.2: 1 h / -70 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 3 h / 25 °C

With n-butyllithium; hydrogen; Dess-Martin periodane; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane;