(+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone

Base Information

• Chemical Name: (+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone
• CAS No.: 218451-40-2
• Molecular Formula: C₂₅H₂₇ClF₂N₄O₄
• Molecular Weight: 520.964
• Mol file: 218451-40-2.mol

Synonyms:(+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone

Chemical Property of (+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone

There total 13 articles about (+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-aminopropyl)-4-(4-chlorophenyl)piperidine-4-carboxamide + 4-(3,4-difluorophenyl)-2-oxo-oxazolidine-3-carboxylic acid-4-nitro-phenyl ester (218449-37-7) → (+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone (218451-40-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; dichloromethane;

Reference yield:

3,4 difluorobenzaldehyde (34036-07-2) → (+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone (218451-40-2)

Guidance literature:

Multi-step reaction with 6 steps

1: methanol; trimethylsilyl cyanide

2: sodium hydroxide; LiAlH₄ / water

3: chloroform; ethyl acetate

4: NaH / tetrahydrofuran; water

5: NaH / tetrahydrofuran; hexane

6: hydrogenchloride / tetrahydrofuran; dichloromethane

With hydrogenchloride; sodium hydroxide; LiAlH₄; NaH; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; trimethylsilyl cyanide; water; ethyl acetate;

Reference yield:

4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester (218451-34-4) → (+)-3-(3-(4-Aminocarbonyl-4-(4-chloro)phenylpiperidin-1-yl)-propyl)aminocarbonyl-4-(3,4-difluoro)phenyl-2-oxazolidinone (218451-40-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH; trifluoroacetic acid / dichloromethane; N,N-dimethyl-formamide

2: conc. H₂ SO₄; dichloromethane

3: hydrogenchloride / tetrahydrofuran; dichloromethane

With hydrogenchloride; NaH; trifluoroacetic acid; In tetrahydrofuran; conc. H₂ SO₄; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-(3,4-difluorophenyl)-2-oxo-oxazolidine-3-carboxylic acid-4-nitro-phenyl ester

4-(4-chloro-phenyl)-4-cyano-piperidine-1-carboxylic acid tert-butyl ester

2-amino-2-(3,4-difluorophenyl)-ethanol

amino-(3,4-difluorophenyl)-acetic acid methyl ester