N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester

Base Information

Chemical Name:N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester
CAS No.:275827-13-9
Molecular Formula:C₂₅H₃₅NO₄Si
Molecular Weight:441.643
Hs Code.:

Synonyms:N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester

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Chemical Property of N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester

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Technology Process of N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester

There total 4 articles about N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 18942-49-9
Boc-D-Phe-OH

: 122760-31-0
2-phenyl-2-(trimethylsilyl)ethanol

: 275827-13-9
N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 4.5h;

Reference yield:

: 16722-09-1
trimethylsilyloxirane

: 275827-13-9
N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI / diethyl ether; hexane

1.2: 87 percent / diethyl ether; hexane / 17.5 h / -50 - -15 °C

2.1: 91 percent / DMAP; 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h / 20 °C

With dmap; copper(l) iodide; dicyclohexyl-carbodiimide; In diethyl ether; hexane; dichloromethane;

Reference yield:

: 754-05-2
ethenyltrimethylsilane

: 275827-13-9
N-(tert-Butyloxycarbonyl)-D-phenylalanin-(2-phenyl-2-trimethylsilyl)ethylester

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / MCPBA / CHCl₃

2: 87 percent / diethyl ether

3: 91 percent / DMAP; DCC / CH₂Cl₂ / 4.5 h / 0 - 20 °C

With dmap; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane; chloroform; 1: Epoxidation / 2: Ring cleavage / 3: Esterification;