5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine

Base Information

Chemical Name:5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine
CAS No.:1380094-16-5
Molecular Formula:C₂₃H₂₃F₂N₅O₂
Molecular Weight:439.465
Hs Code.:

Synonyms:5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine

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Chemical Property of 5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine

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Technology Process of 5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine

There total 11 articles about 5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1380094-27-8
(3S)-3-isothiocyanato-1-methoxy-butane

: 1380094-43-8
3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol

: 1380094-16-5
5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine

Guidance literature:: (3S)-3-isothiocyanato-1-methoxy-butane; 3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol; In ethanol; at 85 ℃; for 16h; Sealed vial;

With dicyclohexyl-carbodiimide; In ethanol; at 85 ℃;

Reference yield:

: 1380094-23-4
(2S)-N-benzyl-4-methoxy-N-[(1S)-1-phenylethyl]butan-2-amine

: 1380094-16-5
5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / 10 wt% Pd(OH)2 on carbon / methanol / 40 h / Inert atmosphere

1.2: 0.5 h

2.1: triethylamine / tetrahydrofuran / Inert atmosphere

3.1: ethanol / 16 h / 85 °C / Sealed vial

3.2: 85 °C

With hydrogen; triethylamine; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 1380094-16-5
5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.17 h / 0 - 5 °C / Inert atmosphere

1.2: 1 h / 30 °C

2.1: disodium hydrogenphosphate; potassium permanganate; sodium dihydrogenphosphate / water; acetone / 5 h / 0 - 15 °C / Inert atmosphere

2.2: 1 h / 15 - 20 °C

3.1: ammonium acetate / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed vial

4.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

4.2: 30 h / pH 8

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

6.1: ethanol / 16 h / 85 °C / Sealed vial

6.2: 85 °C

With potassium permanganate; disodium hydrogenphosphate; sodium dihydrogenphosphate; sulfuric acid; ammonium acetate; hydrogen; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; acetone; acetonitrile;