3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol

Base Information

Chemical Name:3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol
CAS No.:1380094-43-8
Molecular Formula:C₁₇H₁₄F₂N₄O
Molecular Weight:328.321
Hs Code.:

Synonyms:3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol

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Chemical Property of 3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol

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Technology Process of 3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol

There total 6 articles about 3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1380094-40-5
6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-3-nitro-pyridin-2-ol

: 1380094-43-8
3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; Inert atmosphere;

Reference yield:

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 1380094-43-8
3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.17 h / 0 - 5 °C / Inert atmosphere

1.2: 1 h / 30 °C

2.1: disodium hydrogenphosphate; potassium permanganate; sodium dihydrogenphosphate / water; acetone / 5 h / 0 - 15 °C / Inert atmosphere

2.2: 1 h / 15 - 20 °C

3.1: ammonium acetate / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed vial

4.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

4.2: 30 h / pH 8

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

With potassium permanganate; disodium hydrogenphosphate; sodium dihydrogenphosphate; sulfuric acid; ammonium acetate; hydrogen; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; acetone; acetonitrile;

Reference yield:

: 1380094-37-0
6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-3-nitro-pyridin-2-amine

: 1380094-43-8
3-amino-6-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]pyridin-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

1.2: 30 h / pH 8

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

With sulfuric acid; hydrogen; sodium nitrite; palladium 10% on activated carbon; In ethanol; water; dimethyl sulfoxide;