2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester

Base Information

Chemical Name:2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester
CAS No.:946127-58-8
Molecular Formula:C₂₅H₂₃FN₂O₃
Molecular Weight:418.468
Hs Code.:

Synonyms:2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester

Suppliers and Price of 2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester

There total 6 articles about 2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 946127-57-7
[2-(benzhydrylidene-amino)-3-fluoropyridin-4-yl]methanol

: 141-97-9
ethyl acetoacetate

: 946127-58-8
2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester

Guidance literature:: [2-(benzhydrylidene-amino)-3-fluoropyridin-4-yl]methanol; With methanesulfonyl chloride; lithium tert-butoxide; In tetrahydrofuran; at 0 ℃; for 1h;

ethyl acetoacetate; With sodium iodide; lithium tert-butoxide; In tetrahydrofuran; at 50 ℃; for 3h;

Reference yield:

: 946127-54-4
(2-chloro-3-fluoro-pyridin-4-yl)methanol

: 946127-58-8
2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 4.17 h / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: lithium tert-butoxide; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 °C

4.2: 3.5 h / 0 - 50 °C

With 1H-imidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; methanesulfonyl chloride; sodium t-butanolate; lithium tert-butoxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml400379x

Reference yield:

: 946127-55-5
4-(((tert-butyldimethylsilanyl)oxy)methyl)-2-chloro-3-fluoropyridine

: 946127-58-8
2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 4.17 h / 60 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3.1: lithium tert-butoxide; methanesulfonyl chloride / tetrahydrofuran / 1 h / 0 °C

3.2: 3.5 h / 0 - 50 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl ammonium fluoride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; methanesulfonyl chloride; sodium t-butanolate; lithium tert-butoxide; In tetrahydrofuran; toluene;
DOI:10.1021/ml400379x