4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 767321-32-4
• Molecular Formula: C₁₉H₂₃Cl₂NO₄
• Molecular Weight: 400.302
• Mol file: 767321-32-4.mol

Synonyms:4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2,3-Dichlorobenzoic acid methyl ester (2905-54-6) + 4-acetyl-1-(t-butoxycarbonyl)piperidine (206989-61-9) → 4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester (767321-32-4)

Guidance literature:

4-acetyl-1-(t-butoxycarbonyl)piperidine; With lithium hexamethyldisilazane; In 1,2-dimethoxyethane; at -78 - 20 ℃;

2,3-Dichlorobenzoic acid methyl ester; In 1,2-dimethoxyethane; Heating;

DOI:10.1021/jm049967u

Reference yield: 26.0%

methylhydrazine (60-34-4) + 4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester (767321-32-4) → 4-[5-(2,3-dichlorophenyl)-1-methyl-1H-pyrazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester (550377-00-9) + 4-[5-(2,3-dichlorophenyl)-2-methyl-2H-pyrazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester (716371-44-7)

Guidance literature:

In methanol; at 50 ℃; for 1h;

DOI:10.1021/jm049967u

Reference yield:

4-[3-(2,3-dichloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester (767321-32-4) → 4-[5-(2,3-dichloro-phenyl)-1-methyl-1H-pyrazol-3-yl]-piperidine; hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: 7 percent / methanol / 1 h / 50 °C

2: HCl / CH₂Cl₂; dioxane / 2 h / 20 °C

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1021/jm049967u

upstream raw materials:

2,3-Dichlorobenzoic acid methyl ester

4-acetyl-1-(t-butoxycarbonyl)piperidine

Downstream raw materials:

4-[5-(2,3-dichlorophenyl)-1-methyl-1H-pyrazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester

4-[5-(2,3-dichlorophenyl)-2-methyl-2H-pyrazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester

[cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester