(1R,3R,4S)-menthyl (1R,2S,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate

Base Information

Chemical Name:(1R,3R,4S)-menthyl (1R*,2S*,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate
CAS No.:439098-07-4
Molecular Formula:C₃₃H₄₂N₂O₆
Molecular Weight:562.706
Hs Code.:

Synonyms:(1R,3R,4S)-menthyl (1R*,2S*,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate

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Chemical Property of (1R,3R,4S)-menthyl (1R*,2S*,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate

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Technology Process of (1R,3R,4S)-menthyl (1R*,2S*,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate

There total 5 articles about (1R,3R,4S)-menthyl (1R*,2S*,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-3-{1-(2-Acetoxy-ethyl)-4-[indol-1-yl-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxycarbonyl)-methyl]-1,4-dihydro-pyridin-3-yl}-acrylic acid methyl ester

: 439098-07-4
(1R,3R,4S)-menthyl (1R*,2S*,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; benzene; at 60 ℃; for 2h; pH=3.5 - 4;
DOI:10.1016/S0957-4166(02)00055-1

Reference yield:

: 24297-59-4
1-indolylacetic acid

: 439098-07-4
(1R,3R,4S)-menthyl (1R*,2S*,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 57 percent / DMAP; DCC / CH₂Cl₂ / 144 h / 20 °C

2.1: LHMDS / tetrahydrofuran / 0.75 h / -78 °C

2.2: tetrahydrofuran / 1.5 h / -30 °C

3.1: 353 mg / HCl / tetrahydrofuran; benzene / 2 h / 60 °C / pH 3.5 - 4

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/S0957-4166(02)00055-1

Reference yield:

: 2216-51-5
(-)-menthol

: 439098-07-4
(1R,3R,4S)-menthyl (1R*,2S*,6S*)-5-(2-acetoxyethyl)-3-[(E)-2-(methoxycarbonyl)vinyl]-1,2,5,6-tetrahydro-2,6-methano[1,4]diazocino[1,2-a]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 57 percent / DMAP; DCC / CH₂Cl₂ / 144 h / 20 °C

2.1: LHMDS / tetrahydrofuran / 0.75 h / -78 °C

2.2: tetrahydrofuran / 1.5 h / -30 °C

3.1: 353 mg / HCl / tetrahydrofuran; benzene / 2 h / 60 °C / pH 3.5 - 4

With hydrogenchloride; dmap; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1016/S0957-4166(02)00055-1