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24297-59-4

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24297-59-4 Usage

Uses

Indol-1-yl-acetic Acid is a reactant used in the preparation of conformationally restrained analogs of pravadoline; nanomolar potent, enantioselective, (aminoalkyl)?indole agonists of the cannabinoid receptor.

Definition

ChEBI: An indolyl carboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by an indol-1-yl group.

Check Digit Verification of cas no

The CAS Registry Mumber 24297-59-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,2,9 and 7 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 24297-59:
(7*2)+(6*4)+(5*2)+(4*9)+(3*7)+(2*5)+(1*9)=124
124 % 10 = 4
So 24297-59-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO2/c12-10(13)7-11-6-5-8-3-1-2-4-9(8)11/h1-6H,7H2,(H,12,13)

24297-59-4 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (H63935)  1-Indoleacetic acid, 95%   

  • 24297-59-4

  • 250mg

  • 784.0CNY

  • Detail
  • Alfa Aesar

  • (H63935)  1-Indoleacetic acid, 95%   

  • 24297-59-4

  • 1g

  • 1882.0CNY

  • Detail
  • Alfa Aesar

  • (H63935)  1-Indoleacetic acid, 95%   

  • 24297-59-4

  • 5g

  • 7840.0CNY

  • Detail

24297-59-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name indole-1-acetic acid

1.2 Other means of identification

Product number -
Other names 1H-Indole-1-acetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24297-59-4 SDS

24297-59-4Relevant articles and documents

Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database

Doytchinova, Irini,Atanasova, Mariyana,Valkova, Iva,Stavrakov, Georgi,Philipova, Irena,Zhivkova, Zvetanka,Zheleva-Dimitrova, Dimitrina,Konstantinov, Spiro,Dimitrov, Ivan

, p. 768 - 776 (2018)

The inhibition of the enzyme acetylcholinesterase (AChE) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. In the present study, we searched for novel AChE inhibitors by docking-based virtual screening of the standard lead-like set of ZINC database containing more than 6 million small molecules using GOLD software. The top 10 best-scored hits were tested in vitro for AChE affinity, neurotoxicity, GIT and BBB permeability. The main pharmacokinetic parameters like volume of distribution, free fraction in plasma, total clearance, and half-life were predicted by previously derived models. Nine of the compounds bind to the enzyme with affinities from 0.517 to 0.735 μM, eight of them are non-toxic. All hits permeate GIT and BBB and bind extensively to plasma proteins. Most of them are low-clearance compounds. In total, seven of the 10 hits are promising for further lead optimisation. These are structures with ZINC IDs: 00220177, 44455618, 66142300, 71804814, 72065926, 96007907, and 97159977.

TOTAL SYNTHESIS AND STEREOCHEMICAL REASSIGNMENT OF THE INDOLE ALKALOID VINOXINE

Bosch, Joan,Bennasar, M.-Lluisa,Zulaica, Ester,Feliz, Miguel

, p. 3119 - 3122 (1984)

The first total synthesis of the indole alkaloid vinoxine and the reassignment of the relative configuration at carbon-16 in this alkaloid is reported.

Br?nsted Acid-Promoted Cyclodimerization of Indolyl Ketones: Construction of Indole Fused-Oxabicyclo[3.3.1]nonane and -Cyclooctatetraene Ring Systems

Zhao, Lang,Yan, Zhi-Hua,Tang, Shuai,Wei, Zhong-Lin,Liao, Wei-Wei

, p. 166 - 171 (2021)

A Br?nsted acid-promoted cyclodimerization of C(3)-, C(2)-, or N(1)-substituted indole ketone derivatives is described. A wide range of structurally diverse bisindole fused-9-oxabicyclo[3.3.1]nonane and bisindole fused-cyclooctatetraene (COT) derivatives can be prepared in good to high yields with high efficiency.

Chemospecific Cyclizations of α-Carbonyl Sulfoxonium Ylides on Aryls and Heteroaryls

Clare, Daniel,Dobson, Benjamin C.,Inglesby, Phillip A.,A?ssa, Christophe

, p. 16198 - 16202 (2019/11/03)

The functionalization of aryl and heteroaryls using α-carbonyl sulfoxonium ylides without the help of a directing group has remained so far a neglected area, despite the advantageous safety profile of sulfoxonium ylides. Described herein are the cyclizations of α-carbonyl sulfoxonium ylides onto benzenes, benzofurans and N-p-toluenesulfonyl indoles in the presence of a base in HFIP, whereas pyrroles and N-methyl indoles undergo cyclization in the presence of an iridium catalyst. Significantly, these two sets of conditions are chemospecific for each groups of substrates.

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