1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide

Base Information

Chemical Name:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide
CAS No.:1220025-85-3
Molecular Formula:C₂₁H₁₄F₄N₄O
Molecular Weight:414.362
Hs Code.:

Synonyms:1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide

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Chemical Property of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide

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Technology Process of 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide

There total 6 articles about 1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 201230-82-2
carbon monoxide

: 1220165-54-7
4‐bromo‐1‐(4‐fluorophenyl)‐1H‐pyrazolo[3,4‐c]pyridine

: 1220025-85-3
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide

Guidance literature:: With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride; In toluene; at 140 ℃; for 3h; under 11251.1 Torr; Sealed;

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 1220025-85-3
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; sodium acetate / water

2: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate; 1-methyl-pyrrolidin-2-one

3: triethylamine; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / ethanol

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium acetate; potassium carbonate; triethylamine; In ethanol; water;
DOI:10.1016/j.bmcl.2018.12.024

Reference yield:

: 70201-42-2
3,5-dibromopyridine-4-carboxaldehyde

: 1220025-85-3
1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; sodium acetate / water

2: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate; 1-methyl-pyrrolidin-2-one

3: triethylamine; bis(benzonitrile)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / ethanol

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium acetate; potassium carbonate; triethylamine; In ethanol; water;
DOI:10.1016/j.bmcl.2018.12.024