methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride

Base Information

• Chemical Name: methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride
• CAS No.: 179811-83-7
• Molecular Formula: C₁₀H₁₀F₃NO₃*ClH
• Molecular Weight: 285.65
• Mol file: 179811-83-7.mol

Synonyms:methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride

Chemical Property of methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride

There total 2 articles about methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid (261952-24-3) → methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride (179811-83-7)

Guidance literature:

methanol; With thionyl chloride; at 0 ℃; for 0.5h;

2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid; at 0 - 20 ℃; for 16h;

Reference yield: 95.0%

methanol (67-56-1) + 2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid (261952-24-3) → methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride (179811-83-7)

Guidance literature:

methanol; With thionyl chloride; at 0 ℃; for 0.5h;

2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid; at 0 - 20 ℃; for 16h;

Reference yield: 79.0%

methyl 2-amino[4-(trifluoromethoxy)phenyl]acetate hydrochloride (179811-83-7) → 2-amino-2-(4-(trifluoromethoxy)phenyl)acetamide (950651-11-3)

Guidance literature:

With ammonia; In water; at 20 ℃; for 16h;

upstream raw materials:

2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid

methanol

Downstream raw materials:

2-amino-2-(4-(trifluoromethoxy)phenyl)acetamide

(2-oxo-3-{4-[(trifluoromethyl)oxy]phenyl}-1,4-diazaspiro[4.5]dec-3-en-1-yl)acetic acid

(2-oxo-3-{4-[(trifluoromethyl)oxy]phenyl}-1,4-diazaspiro[4.5]dec-3-en-1-yl)acetyl chloride

ethyl (2-oxo-3-{4-[(trifluoromethyl)oxy]phenyl}-1,4-diazaspiro[4.5]dec-3-en-1-yl)acetate