N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine

Base Information

• Chemical Name: N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine
• CAS No.: 95413-95-9
• Molecular Formula: C₁₉H₂₄FNO₄
• Molecular Weight: 349.402

Synonyms:N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine

Chemical Property of N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine

Chemical Property:

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Technology Process of N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine

There total 12 articles about N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-<2-(4-methoxyphenyl)-2-hydroxyethyl>-2-(3,4-dimethoxy-2-fluorophenyl)acetamide (104421-99-0) → N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine (95413-95-9)

Guidance literature:

With borane; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00384a006

Reference yield:

4-Methoxystyrene (637-69-4,24936-44-5) → N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine (95413-95-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 86.4 percent / Br₂ / CH₂Cl₂ / -5 - 0 °C

2: 95 percent / MgSO₄, MgO / 1.25 h / Heating

3: K₂CO₃ / dimethylformamide / 2 h / 110 °C

4: 10percent aq. H₂SO₄ / Heating

With sulfuric acid; bromine; magnesium oxide; magnesium sulfate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00161a029

Reference yield:

1-((4-methoxy)phenyl)-1,2-dibromoethane (19484-05-0) → N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine (95413-95-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / MgSO₄, MgO / 1.25 h / Heating

2: K₂CO₃ / dimethylformamide / 2 h / 110 °C

3: 10percent aq. H₂SO₄ / Heating

With sulfuric acid; magnesium oxide; magnesium sulfate; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm00161a029

upstream raw materials:

N-<2-(4-methoxyphenyl)-2-hydroxyethyl>-2-(3,4-dimethoxy-2-fluorophenyl)acetamide

4-Methoxystyrene

1-((4-methoxy)phenyl)-1,2-dibromoethane

2-bromo-1-(tert-butoxy)-1-(4-methoxyphenyl)ethane

Downstream raw materials:

N-allyl-6-fluoro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrobromide

3-Allyl-6-fluoro-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

6-Fluoro-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

6-Fluoro-1-(4-hydroxy-phenyl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrobromide

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