ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate

Base Information

Chemical Name:ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate
CAS No.:460997-45-9
Molecular Formula:C₂₇H₃₈O₃Si
Molecular Weight:438.682
Hs Code.:

Synonyms:ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate

Suppliers and Price of ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate

There total 7 articles about ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 460997-44-8
ethyl (E),(4R)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pent-2-enoate

: 460997-45-9
ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethyl acetate; at 20 ℃;
DOI:10.1002/1521-3773(20020617)41:12<2144::AID-ANIE2144>3.0.CO;2-E

Reference yield:

: 334705-97-4
(1S,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-1-isopropenylcyclopropane

: 460997-45-9
ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: BH₃*THF / tetrahydrofuran / 2.5 h / -30 - 20 °C

1.2: 91 percent / aq. NaOH; aq. H₂O₂ / tetrahydrofuran / 3 h / 20 °C

2.1: PCC / CH₂Cl₂ / 1.5 h / 20 °C

3.1: 10.7 g / NaH / tetrahydrofuran / 1 h / 20 °C

4.1: 97 percent / H₂ / PtO₂ / ethyl acetate / 6 h

With borane-THF; hydrogen; sodium hydride; pyridinium chlorochromate; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; ethyl acetate; 3.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo0496042

Reference yield:

: 460997-43-7
(2R)-2-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)propan-1-ol

: 460997-45-9
ethyl (4S)-4-((1R,2R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}cyclopropyl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: PCC / CH₂Cl₂ / 1.5 h / 20 °C

2: 10.7 g / NaH / tetrahydrofuran / 1 h / 20 °C

3: 97 percent / H₂ / PtO₂ / ethyl acetate / 6 h

With hydrogen; sodium hydride; pyridinium chlorochromate; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; ethyl acetate; 2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo0496042