1,2-Benzenediol, 4-fluoro-5-[1-hydroxy-2-(methylamino)ethyl]- (9CI)

Base Information

Chemical Name:1,2-Benzenediol, 4-fluoro-5-[1-hydroxy-2-(methylamino)ethyl]- (9CI)
CAS No.:115562-28-2
Molecular Formula:C9H12 F N O3
Molecular Weight:492.431
Hs Code.:
Mol file:115562-28-2.mol

Synonyms:1,2-Benzenediol,4-fluoro-5-[1-hydroxy-2-(methylamino)ethyl]-, (?à)-

Suppliers and Price of 1,2-Benzenediol, 4-fluoro-5-[1-hydroxy-2-(methylamino)ethyl]- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 1,2-Benzenediol, 4-fluoro-5-[1-hydroxy-2-(methylamino)ethyl]- (9CI)

Chemical Property:

PSA：147.32000
LogP:0.03620

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,2-Benzenediol, 4-fluoro-5-[1-hydroxy-2-(methylamino)ethyl]- (9CI)

There total 7 articles about 1,2-Benzenediol, 4-fluoro-5-[1-hydroxy-2-(methylamino)ethyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 144-62-7,97993-78-7
oxalic acid

: 115562-27-1
1-(4,5-Bis-benzyloxy-2-fluoro-phenyl)-2-methylamino-ethanol

: 115562-28-2
4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 6h; under 2068.6 Torr;
DOI:10.1021/jm00118a019

Reference yield:

: 71924-62-4
2-fluoro-4,5-dimethoxybenzaldehyde

: 115562-28-2
4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) BBr₃

3: LiAlH₄

4: 89 percent / 4 h / Heating

5: 68 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

6: 73 percent / H₂ / 10percent Pd/C / methanol / 6 h / 2068.6 Torr

With lithium aluminium tetrahydride; hydrogen; boron tribromide; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00118a019

Reference yield:

: 71924-67-9
4,5-bis(benzyloxy)-2-fluorobenzaldehyde

: 115562-28-2
4-Fluoro-5-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid

Guidance literature:: Multi-step reaction with 5 steps

2: LiAlH₄

3: 89 percent / 4 h / Heating

4: 68 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

5: 73 percent / H₂ / 10percent Pd/C / methanol / 6 h / 2068.6 Torr

With lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00118a019