2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine

Base Information

Chemical Name:2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine
CAS No.:923931-03-7
Molecular Formula:C₂₄H₂₈N₂O₃S
Molecular Weight:424.564
Hs Code.:

Synonyms:2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine

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Chemical Property of 2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine

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Technology Process of 2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine

There total 7 articles about 2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 923930-98-7
2-((R)-1-acetoxyethyl)-6-[(S)-1-(methanesulfonyloxy)ethyl]pyridine

: 923931-03-7
2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / diisopropylethylamine / acetonitrile / 60 °C

2: K₂CO₃ / methanol / 0.17 h / 20 °C

3: triethylamine; 4-(dimethylamino)pyridine / 0.75 h / 20 °C

With dmap; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile;
DOI:10.1021/jo061729e

Reference yield:

: 923931-00-4
2-((R)-1-acetoxyethyl)-6-{(R)-1-[(R)-1-phenylethyl]aminoethyl}pyridine

: 923931-03-7
2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / methanol / 0.17 h / 20 °C

2: triethylamine; 4-(dimethylamino)pyridine / 0.75 h / 20 °C

With dmap; potassium carbonate; triethylamine; In methanol;
DOI:10.1021/jo061729e

Reference yield:

: 1129-30-2
2,6-Diacetylpyridine

: 923931-03-7
2-{(R)-1-[(R)-1-phenylethyl]aminoethyl}-6-[(R)-1-(p-toluenesulfonyloxy)ethyl]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / NaBH₄ / methanol / 1 h / 20 °C

2: 45 percent / Novozym 435; molecular sieves 4 Angstroem / diisopropyl ether / 10 h / 20 °C

3: 100 percent / triethylamine / CH₂Cl₂ / 0.17 h / 20 °C

4: 84 percent / diisopropylethylamine / acetonitrile / 60 °C

5: K₂CO₃ / methanol / 0.17 h / 20 °C

6: triethylamine; 4-(dimethylamino)pyridine / 0.75 h / 20 °C

With dmap; sodium tetrahydroborate; Novozym 435; 4 A molecular sieve; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; di-isopropyl ether; acetonitrile;
DOI:10.1021/jo061729e