2-(HYDROXY-P-TOLYL-METHYL)-ACRYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-(HYDROXY-P-TOLYL-METHYL)-ACRYLIC ACID METHYL ESTER
• CAS No.: 115240-91-0
• Molecular Formula: C12H14 O3
• Molecular Weight: 206.241
• Hs Code.: 2918199090
• Mol file: 115240-91-0.mol

Synonyms:Methyl3-hydroxy-2-methylene-3-(4-methylphenyl)propanoate; Methyl3-hydroxy-3-(p-tolyl)-2-methylenepropanoate

Chemical Property of 2-(HYDROXY-P-TOLYL-METHYL)-ACRYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 46.53000
• LogP: 1.75760
• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

Methyl2-(hydroxy(p-tolyl)methyl)acrylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(HYDROXY-P-TOLYL-METHYL)-ACRYLIC ACID METHYL ESTER

There total 8 articles about 2-(HYDROXY-P-TOLYL-METHYL)-ACRYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-benzaldehyde (104-87-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 2-((hydroxy)(4-methylphenyl)methyl)prop-2-enoate (115240-91-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; formamide; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1002/adsc.201300846

Reference yield: 99.0%

methyl 2-((tert-butoxycarbonyloxy)(4-methylphenyl)methyl)acrylate (1187847-13-7) → methyl 2-((hydroxy)(4-methylphenyl)methyl)prop-2-enoate (115240-91-0)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; water; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

DOI:10.1021/jo201096e

Reference yield: 91.0%

methanol (67-56-1) + 4-methyl-benzaldehyde (104-87-0) → methyl 2-((hydroxy)(4-methylphenyl)methyl)prop-2-enoate (115240-91-0)

Guidance literature:

Multistep reaction.;

DOI:10.1055/s-2007-966013

upstream raw materials:

4-methyl-benzaldehyde

acrylic acid methyl ester

Methyl 2-bromopropionate

methanol

Downstream raw materials:

methyl 2-methyl-3-(4-methylphenyl)-3-oxopropanoate

methyl 2-(acetoxy(4-methylphenyl)methyl)acrylate

methyl (2Z)-2-(bromomethyl)-3-(4-methylphenyl)prop-2-enoate

Refernces

• 1、 Zhou, Bo,Li, Long,Liu, Xin,Tan, Tong-De,Liu, Jinxian,Ye, Long-Wu. "Yttrium-catalyzed tandem intermolecular hydroalkoxylation/ claisen rearrangement". . p. 10149 - 10157. Retrieved 2017.
• 2、 Amarante, Giovanni W.,Camilo, Nilton S.,Carpanez, Arthur G.,Coelho, Fernando,Fernandes, Fábio S.,Lima, Samia R.,Rodrigues, Manoel T.,Santos, Hugo,Serafim, José Cláudio,Silva, Thiago S.,Zeoly, Lucas A.,de Oliveira, Aline S. B.. "An Improved Protocol for the Morita-Baylis-Hillman Reaction Allows Unprecedented Broad Synthetic Scope". supporting information. . Retrieved 2022/01/22.
• 3、 Schaufelberger, Fredrik,Ramstr?m, Olof. "Activated Self-Resolution and Error-Correction in Catalytic Reaction Networks**". supporting information. p. 10335 - 10340. Retrieved 2021/05/07.