N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide

Base Information

Chemical Name:N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide
CAS No.:1357620-18-8
Molecular Formula:C₂₂H₂₈N₄O₄
Molecular Weight:412.489
Hs Code.:

Synonyms:N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide

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Chemical Property of N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide

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Technology Process of N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide

There total 13 articles about N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1357620-17-7
N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-N'-(3-(dimethylamino)propyl) terephthalamide

: 1357620-18-8
N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2015.12.090

Reference yield: 55.0%

: 1018449-03-0
C₁₅H₂₆N₂O₂Si

: 1155168-52-7
4-(3-(dimethylamino)propylcarbamoyl)benzoic acid

: 1357620-18-8
N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide

: 1357620-17-7
N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-N'-(3-(dimethylamino)propyl) terephthalamide

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tet.2011.12.030

Reference yield:

: 1041198-49-5
3-acetamido-5-nitrobenzyl acetate

: 1357620-18-8
N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water; ethanol / 3 h

2.1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

4.1: dmap / N,N-dimethyl-formamide / Inert atmosphere

4.2: 0.03 h / Inert atmosphere

4.3: 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; dmap; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.12.090