1-(3-AMINO-10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-2-DIMETHYLAMINO-ETHANONE

Base Information

• Chemical Name: 1-(3-AMINO-10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-2-DIMETHYLAMINO-ETHANONE
• CAS No.: 102821-91-0
• Molecular Formula: C₁₈H₂₁N₃O
• Molecular Weight: 295.384
• Mol file: 102821-91-0.mol

Synonyms:3-amino-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenzazepine

Chemical Property of 1-(3-AMINO-10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-2-DIMETHYLAMINO-ETHANONE

Chemical Property:

• Melting Point: 124-126 °C
• Boiling Point: 535.1±50.0 °C(Predicted)
• PKA: 6.99±0.28(Predicted)
• Density: 1.187±0.06 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-Amino-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-2-dimethylamino-ethanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

Useful:

• Uses: 1-(3-Amino-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-2-dimethylamino-ethanone (CAS# 102821-91-0) can be used for its immunochemical properties toward anti-arrhythmic activity.

Technology Process of 1-(3-AMINO-10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-2-DIMETHYLAMINO-ETHANONE

There total 5 articles about 1-(3-AMINO-10,11-DIHYDRO-DIBENZO[B,F]AZEPIN-5-YL)-2-DIMETHYLAMINO-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

[5-(2-Dimethylamino-acetyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-3-yl]-carbamic acid ethyl ester; hydrochloride (78816-67-8) → 3-amino-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenzazepine (102821-91-0)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1007/BF00766590

Reference yield:

3-amino-10,11-dihydro-5H-dibenzazepine (10464-35-4) → 3-amino-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenzazepine (102821-91-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Na₂CO₃ / acetone; H₂O / 1.5 h

2: toluene / 4 h / Heating

3: toluene / 4 h / 70 - 110.8 °C

4: HCl in isopropanol / propan-2-ol

5: 75 percent / 4 M NaOH / ethanol / 2 h / Heating

With hydrogenchloride; sodium hydroxide; sodium carbonate; In ethanol; water; isopropyl alcohol; acetone; toluene;

Reference yield:

3-carbethoxyamino-10,11-dihydro-5H-dibenzazepine (78816-40-7) → 3-amino-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenzazepine (102821-91-0)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / 4 h / Heating

2: toluene / 4 h / 70 - 110.8 °C

3: HCl in isopropanol / propan-2-ol

4: 75 percent / 4 M NaOH / ethanol / 2 h / Heating

With hydrogenchloride; sodium hydroxide; In ethanol; isopropyl alcohol; toluene;

upstream raw materials:

[5-(2-Dimethylamino-acetyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-3-yl]-carbamic acid ethyl ester; hydrochloride

3-amino-10,11-dihydro-5H-dibenzazepine

3-carbethoxyamino-10,11-dihydro-5H-dibenzazepine

3-carbethoxyamino-5-chloroacetyl-10,11-dihydro-5H-dibenzazepine

Downstream raw materials:

3-(4-aminobenzoylamino)-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenz[b,f]azepine

5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine