5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine

Base Information

• Chemical Name: 5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine
• CAS No.: 220194-92-3
• Molecular Formula: C₂₅H₂₄N₄O₄
• Molecular Weight: 444.49
• Mol file: 220194-92-3.mol

Synonyms:5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine

Chemical Property of 5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine

There total 1 articles about 5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-nitro-benzoyl chloride (122-04-3) + 3-amino-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenzazepine (102821-91-0) → 5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine (220194-92-3)

Guidance literature:

With sodium carbonate; In ethanol; acetone; at 10 - 12 ℃; for 1h;

DOI:10.1007/BF02539228

Reference yield: 73.0%

5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine (220194-92-3) → 3-(4-aminobenzoylamino)-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenz[b,f]azepine (220194-94-5)

Guidance literature:

With hydrazine hydrate; nickel; In ethanol; acetone; for 2h; Heating;

DOI:10.1007/BF02539228

Reference yield:

5-dimethylaminoacetyl-3-(4-nitrobenzoylamino)-10,11-dihydro-5H-dibenz[b,f]azepine (220194-92-3) → 3-(4-acetylaminobenzoylamino)-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenz[b,f]azepine

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / hydrazine hydrate / Raney nickel / ethanol; acetone / 2 h / Heating

2: 1.5 h / 65 - 70 °C

With hydrazine hydrate; nickel; In ethanol; acetone; 1: Reduction / 2: Acetylation;

DOI:10.1007/BF02539228

upstream raw materials:

4-nitro-benzoyl chloride

3-amino-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenzazepine

Downstream raw materials:

3-(4-aminobenzoylamino)-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenz[b,f]azepine