2-Iodo-3-methoxy-6-nitropyridine

Base Information

• Chemical Name: 2-Iodo-3-methoxy-6-nitropyridine
• CAS No.: 115170-07-5
• Molecular Formula: C₆H₅IN₂O₃
• Molecular Weight: 280.022
• Mol file: 115170-07-5.mol

Synonyms:2-Iodo-3-methoxy-6-nitropyridine

Chemical Property of 2-Iodo-3-methoxy-6-nitropyridine

Chemical Property:

• PSA: 67.94000
• LogP: 2.12620

Purity/Quality:

98%min ^*data from raw suppliers

2-Iodo-3-methoxy-6-nitro-pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Iodo-3-methoxy-6-nitropyridine

There total 5 articles about 2-Iodo-3-methoxy-6-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-iodo-3-methoxy-pyridine (93560-55-5) → 3-Methoxy-2,6-dinitropyridin + 2-Iod-3-methoxy-6-nitropyridin (115170-07-5)

Guidance literature:

With sulfuric acid; nitric acid; Ambient temperature;

Reference yield: 34.0%

2-Iod-3-methoxy-6-nitropyridin-1-oxid (115170-06-4) → 2-Iod-3-methoxy-6-nitropyridin (115170-07-5)

Guidance literature:

With phosphorus trichloride; In chloroform; for 1h; Heating;

Reference yield:

2-iodo-3-hydroxypyridine (40263-57-8) → 2-Iod-3-methoxy-6-nitropyridin (115170-07-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) KOH / 1) DMSO, 50 deg C, 20 min, 2) DMSO, 50 deg C, 30 min

2: 67.9 percent / 30percent H₂O₂ / acetic anhydride / Ambient temperature

3: 64.4 percent / conc. H₂SO₄, 100percent HNO₃ / Ambient temperature

4: 34 percent / PCl₃ / CHCl₃ / 1 h / Heating

With potassium hydroxide; sulfuric acid; dihydrogen peroxide; nitric acid; phosphorus trichloride; In chloroform; acetic anhydride;

upstream raw materials:

2-iodo-3-methoxy-pyridine

2-Iod-3-methoxy-6-nitropyridin-1-oxid

2-iodo-3-hydroxypyridine

2-iodo-3-methoxypyridine 1-oxide

Downstream raw materials:

2,3-Dimethoxy-6-nitropyridin

Refernces