2,3-Dimethoxy-6-nitropyridine

Base Information

• Chemical Name: 2,3-Dimethoxy-6-nitropyridine
• CAS No.: 79491-44-4
• Molecular Formula: C7H8 N2 O4
• Molecular Weight: 184.15
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50509114
• Wikidata: Q82366482
• Mol file: 79491-44-4.mol

Synonyms:2,3-DIMETHOXY-6-NITROPYRIDINE;79491-44-4;SCHEMBL4158236;DTXSID50509114;QDBVUQQJSXYDHF-UHFFFAOYSA-N;MFCD11044329;AKOS006308360;SB53607;BS-24349;2,3-Dimethoxy-6-nitropyridine, AldrichCPR;CS-0089781;FT-0742854

Chemical Property of 2,3-Dimethoxy-6-nitropyridine

Chemical Property:

• PSA: 77.17000
• LogP: 1.53020
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 184.04840674
• Heavy Atom Count: 13
• Complexity: 182

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dimethoxy-6-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(N=C(C=C1)[N+](=O)[O-])OC

Technology Process of 2,3-Dimethoxy-6-nitropyridine

There total 9 articles about 2,3-Dimethoxy-6-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methanol (67-56-1) + 2-bromo-3-methoxy-6-nitropyridine (76066-07-4) → 2,3-Dimethoxy-6-nitropyridin (79491-44-4)

Guidance literature:

With sodium; In dimethyl sulfoxide; at 30 ℃; for 2h;

Reference yield: 80.4%

methanol (67-56-1) + 2-Iod-3-methoxy-6-nitropyridin (115170-07-5) → 2,3-Dimethoxy-6-nitropyridin (79491-44-4)

Guidance literature:

With sodium methylate; Heating;

Reference yield: 76.0%

sodium methylate (124-41-4) + 2-bromo-3-methoxy-6-nitropyridine (76066-07-4) → 2,3-Dimethoxy-6-nitropyridin (79491-44-4)

Guidance literature:

In methanol; dimethyl sulfoxide; at 20 - 35 ℃; for 49.5h;

upstream raw materials:

methanol

2-bromo-3-methoxy-6-nitropyridine

2-Iod-3-methoxy-6-nitropyridin

2-iodo-3-hydroxypyridine

Downstream raw materials:

5,6-dimethoxypyridin-2-amine