[(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol

Base Information

Chemical Name:[(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol
CAS No.:380223-70-1
Molecular Formula:C₁₂H₁₄BrNO₃
Molecular Weight:300.152
Hs Code.:

Synonyms:[(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol

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Chemical Property of [(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol

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Technology Process of [(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol

There total 4 articles about [(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 380223-68-7
(4R,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

: 380223-70-1
[(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -30 ℃; for 0.25h;
DOI:10.1016/S0960-894X(01)00484-X

Reference yield:

: 62910-63-8
5-bromo-2-methoxybenzoyl chloride

: 380223-70-1
[(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CHCl₃ / 0.08 h / -5 °C

1.2: 78 percent / Et₃N / CHCl₃ / 0.25 h / 0 - 20 °C

2.1: 70 percent / MeO₂CNSO₂NEt₃ / tetrahydrofuran / 0.75 h / 70 °C

3.1: 53 percent / LiAlH₄ / diethyl ether / 0.25 h / -30 °C

With lithium aluminium tetrahydride; Burgess Reagent; triethylamine; In tetrahydrofuran; diethyl ether; chloroform;
DOI:10.1016/S0960-894X(01)00484-X

Reference yield:

: 2476-35-9
5-bromo-2-methoxybenzoic acid

: 380223-70-1
[(4S,5R)-2-(5-Bromo-2-methoxy-phenyl)-5-methyl-4,5-dihydro-oxazol-4-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: SOCl₂; DMF / toluene; CHCl₃ / 15 h / 60 °C

2.1: Et₃N / CHCl₃ / 0.08 h / -5 °C

2.2: 78 percent / Et₃N / CHCl₃ / 0.25 h / 0 - 20 °C

3.1: 70 percent / MeO₂CNSO₂NEt₃ / tetrahydrofuran / 0.75 h / 70 °C

4.1: 53 percent / LiAlH₄ / diethyl ether / 0.25 h / -30 °C

With lithium aluminium tetrahydride; thionyl chloride; Burgess Reagent; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; chloroform; toluene;
DOI:10.1016/S0960-894X(01)00484-X