(S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine

Base Information

Chemical Name:(S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine
CAS No.:214753-58-9
Molecular Formula:C₄₀H₄₆N₂O₆Si
Molecular Weight:678.901
Hs Code.:

Synonyms:(S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine

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Technology Process of (S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine

There total 3 articles about (S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 214753-93-2
(S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine benzyl ester

: 214753-58-9
(S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1.25h;
DOI:10.1016/S0968-0896(98)00089-3

Reference yield:

: 88574-06-5
6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid

: 214753-58-9
(S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / HBTU; Et₃N / CH₂Cl₂ / 20 °C

2: 69 percent / imidazole / tetrahydrofuran / 15 h / 20 °C

3: 94 percent / H₂ / Pd-C / methanol / 1.25 h / 20 °C

With 1H-imidazole; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 1: Acylation / 2: Substitution / 3: Hydrogenolysis;
DOI:10.1016/S0968-0896(98)00089-3

Reference yield:

: 214753-53-4
(S)-N-[6-(N-fluorenylmethoxycarbonylamino)hexanoyl]serine benzyl ester

: 214753-58-9
(S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / imidazole / tetrahydrofuran / 15 h / 20 °C

2: 94 percent / H₂ / Pd-C / methanol / 1.25 h / 20 °C

With 1H-imidazole; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; 1: Substitution / 2: Hydrogenolysis;
DOI:10.1016/S0968-0896(98)00089-3