Technology Process of (E)-2-(p-toluenesulfonyl)-2,3,6,7-tetrahydro-1H-benzo[c]azonine
There total 5 articles about (E)-2-(p-toluenesulfonyl)-2,3,6,7-tetrahydro-1H-benzo[c]azonine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; toluene;
at -78 - 0 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/anie.201204484
- Guidance literature:
-
With
diethyl isophthalate;
In
diethyl ether; pentane;
at 20 ℃;
for 12h;
UV-irradiation;
Inert atmosphere;
DOI:10.1246/cl.170937
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0.17 h / 0 °C / Inert atmosphere
1.2: 1 h / -78 - 0 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 1 h / -78 - 0 °C / Inert atmosphere
4.1: diisobutylaluminium hydride / hexane; dichloromethane / 0.5 h / -78 °C / Inert atmosphere
5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 2 h / -78 - 0 °C / Inert atmosphere
With
sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; hexane; dichloromethane; toluene; mineral oil;
1.1: |Mitsunobu Displacement / 1.2: |Mitsunobu Displacement / 2.1: |Dess-Martin Oxidation / 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination / 5.1: |Mitsunobu Displacement;
DOI:10.1002/anie.201204484
![N-{2-[(E)-5-hydroxypent-3-en-1-yl]benzyl}-p-toluenesulfonamide](/Databaselist/images/loading.webp)
