N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide

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Chemical Name:N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide
CAS No.:1282606-72-7
Molecular Formula:C₂₈H₂₃F₃N₆O₃
Molecular Weight:548.524
Hs Code.:

Synonyms:N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide

There total 4 articles about N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1282606-69-2
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

: 72235-53-1
3,4-difluorobenzylamine

: 1282606-72-7
N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide

Guidance literature:: 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

3,4-difluorobenzylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 625386-10-9
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-72-7
N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2.1: pyridine / dichloromethane / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: toluene-4-sulfonic acid / methanol / 0.17 h / 90 °C / microwave irradiation

4.1: potassium carbonate / acetone / 3.5 h / Reflux

5.1: sodium hydroxide / ethanol / 2 h / Reflux

5.2: pH 2 - 3

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 18 h / 20 °C

With pyridine; hydrogen; potassium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1282606-68-1
methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

: 1282606-72-7
N-(3,4-difluorobenzyl)-3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 2 h / Reflux

1.2: pH 2 - 3

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 18 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;