methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

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Chemical Name:methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate
CAS No.:1282606-68-1
Molecular Formula:C₂₂H₂₀FN₅O₄
Molecular Weight:437.43
Hs Code.:

Synonyms:methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

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Chemical Property of methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

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Technology Process of methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

There total 6 articles about methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1282606-64-7
methyl 1-(4-methoxybenzyl)-3-(5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1H-pyrazole-5-carboxylate

: 459-46-1
4-Fluorobenzyl bromide

: 1282606-68-1
methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: With potassium carbonate; In acetone; for 3.5h; Reflux;

Reference yield:

: 181585-93-3
5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-68-1
methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / 2 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3.1: pyridine / dichloromethane / 0 - 20 °C

3.2: 1 h / 20 °C

4.1: toluene-4-sulfonic acid / methanol / 0.17 h / 90 °C / microwave irradiation

5.1: potassium carbonate / acetone / 3.5 h / Reflux

With pyridine; hydrogen; potassium carbonate; toluene-4-sulfonic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetone;

Reference yield:

: 625386-10-9
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-68-1
methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2.1: pyridine / dichloromethane / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: toluene-4-sulfonic acid / methanol / 0.17 h / 90 °C / microwave irradiation

4.1: potassium carbonate / acetone / 3.5 h / Reflux

With pyridine; hydrogen; potassium carbonate; toluene-4-sulfonic acid; palladium 10% on activated carbon; In methanol; dichloromethane; acetone;