3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

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Chemical Name:3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid
CAS No.:1282606-69-2
Molecular Formula:C₂₁H₁₈FN₅O₄
Molecular Weight:423.403
Hs Code.:

Synonyms:3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

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Chemical Property of 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

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Technology Process of 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

There total 6 articles about 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1282606-68-1
methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

: 1282606-69-2
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: methyl 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate; With sodium hydroxide; In ethanol; for 2h; Reflux;

With hydrogenchloride; In ethanol; water; pH=2 - 3;

Reference yield:

: 625386-10-9
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 1282606-69-2
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

2.1: pyridine / dichloromethane / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: toluene-4-sulfonic acid / methanol / 0.17 h / 90 °C / microwave irradiation

4.1: potassium carbonate / acetone / 3.5 h / Reflux

5.1: sodium hydroxide / ethanol / 2 h / Reflux

5.2: pH 2 - 3

With pyridine; hydrogen; potassium carbonate; toluene-4-sulfonic acid; sodium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; acetone;

Reference yield:

: 1282606-65-8
methyl 3-(hydrazinecarboxamido)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate

: 1282606-69-2
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / methanol / 0.17 h / 90 °C / microwave irradiation

2.1: potassium carbonate / acetone / 3.5 h / Reflux

3.1: sodium hydroxide / ethanol / 2 h / Reflux

3.2: pH 2 - 3

With potassium carbonate; toluene-4-sulfonic acid; sodium hydroxide; In methanol; ethanol; acetone;