1-methoxy-3-phenylpyridazin-1-ium methyl sulfate

Base Information

• Chemical Name: 1-methoxy-3-phenylpyridazin-1-ium methyl sulfate
• CAS No.: 58550-24-6
• Molecular Formula: CH₃O₄S*C₁₁H₁₁N₂O
• Molecular Weight: 298.32
• Mol file: 58550-24-6.mol

Synonyms:1-methoxy-3-phenylpyridazin-1-ium methyl sulfate

Chemical Property of 1-methoxy-3-phenylpyridazin-1-ium methyl sulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxy-3-phenylpyridazin-1-ium methyl sulfate

There total 3 articles about 1-methoxy-3-phenylpyridazin-1-ium methyl sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

dimethyl sulfate (77-78-1) + 3-phenylpyridazine 1-oxide (33471-42-0) → 1-methoxy-3-phenylpyridazin-1-ium methyl sulfate (58550-24-6)

Guidance literature:

at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03064

Reference yield:

3-phenylpyridazine (15150-84-2) → 1-methoxy-3-phenylpyridazin-1-ium methyl sulfate (58550-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: 2 h / 70 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/acs.orglett.5b03064

Reference yield:

phenylboronic acid (98-80-6) → 1-methoxy-3-phenylpyridazin-1-ium methyl sulfate (58550-24-6)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane

3: 2 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,2-dimethoxyethane; dichloromethane; water;

DOI:10.1021/acs.orglett.5b03064

upstream raw materials:

dimethyl sulfate

3-phenylpyridazine 1-oxide

3-phenylpyridazine

phenylboronic acid

Refernces