15150-84-2

Basic information

• Product Name: 3-PHENYL-PYRIDAZINE
• Synonyms: AURORA KA-559;3-PHENYL-PYRIDAZINE
• CAS NO: 15150-84-2
• Molecular Formula: C₁₀H₈N₂
• Molecular Weight: 156.18
• Mol File: 15150-84-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 98 °C
• Boiling Point: 347.9 °C at 760 mmHg
• Flash Point: 166.2 °C
• Appearance: /
• Density: 1.106 g/cm³
• Vapor Pressure: 0.000105mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• PKA: 2.52±0.10(Predicted)
• CAS DataBase Reference: 3-PHENYL-PYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-PYRIDAZINE(15150-84-2)
• EPA Substance Registry System: 3-PHENYL-PYRIDAZINE(15150-84-2)

Safety Data

• Hazardous Substances Data: 15150-84-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 5703, 1995 DOI: 10.1016/0040-4039(95)01128-5

InChI:InChI=1/C10H8N2/c1-2-5-9(6-3-1)10-7-4-8-11-12-10/h1-8H

Upstream product

• 289-80-5 1,2-diazine 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 100-52-7 benzaldehyde 
• 6249-80-5 1-phenylbut-3-en-1-one 
• 70-11-1 α-bromoacetophenone 
• 64878-08-6 2-(allylthio)-1-phenylethan-1-one 
• 2164-61-6 pyridazine-3-carboxylic acid 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 
• 1120-95-2 3-chloropyridazine 
• 98-80-6 phenylboronic acid 
• 1011-46-7 6-phenyl-2,3,4,5-tetrahydropyridazin-3-one 
• 2166-31-6 6-phenylpyridazin-3(2H)-one 

Downstream Products

• 91799-33-6 3-phenyl-hexahydro-pyridazine 
• 33471-42-0 3-phenylpyridazine 1-oxide 
• 58550-24-6 1-methoxy-3-phenylpyridazin-1-ium methyl sulfate 
• 1140-08-5 2-methyl-7-phenyl-1H-indole 
• 475633-70-6 3-iodo-6-phenylpyridazine 
• 20375-65-9 3-chloro-6-phenylpyradazine 
• 109854-67-3 3-(methylthio)-6-phenylpyridazine 
• 99974-22-8 6-phenylpyridazine-3-carbaldehyde 
• 172879-50-4 3-Phenyl-4-(p-tolylsulfonylmethyl)pyridazinium 1-dicyanomethylide 

Relevant articles and documents

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Lewis Acid Directed Regioselective Metalations of Pyridazine

Mono- or bidentate boron Lewis acids trigger a regioselective magnesiation or zincation of pyridazine in position C3 (ortho product) or C4 (meta product). The regioselectivity of the metalation was rationalized with the help of calculated pKa values of both pyridazine and pyridazine/Lewis acid complexes.

Copper-Promoted 6- endo-trig Cyclization of β,γ-Unsaturated Hydrazones for the Synthesis of 1,6-Dihydropyridazines

A novel and efficient strategy for the synthesis of 1,6-dihydropyridazines via copper-promoted 6-endo-trig cyclization of readily available β,γ-unsaturated hydrazones have been developed. A series of 1,6-dihydropyridazines have been synthesized by this method with good yields, high functional group tolerance, and remarkable regioselectivity under mild conditions. Importantly, the 1,6-dihydropyridazines can be efficiently converted to biologically important pyridazines in the presence of NaOH.

Synthesis of Functionalized β-Keto Arylthioethers by the Aryne Induced [2,3] Stevens Rearrangement of Allylthioethers

A mild and transition-metal-free synthesis of β-keto arylthioethers has been developed by the aryne triggered [2,3] Stevens rearrangement of allylthioethers. The key sulfur ylide intermediate for the rearrangement was formed by the S-arylation of allylthi