Technology Process of (S)-N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-2,5-dibromopyridin-3-yl)-2,2,2-trifluoroacetamide TFA salt
There total 10 articles about (S)-N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-2,5-dibromopyridin-3-yl)-2,2,2-trifluoroacetamide TFA salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
dichloromethane;
at 0 - 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: sodium acetate; acetic acid / Reflux
2: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C
3: copper(II) sulfate / dichloromethane / 2 h / 20 °C
4: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C
5: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C
6: triethylamine / dichloromethane / 0 °C
7: hydrazine hydrate / ethanol / 2 h / 20 °C
8: N-Bromosuccinimide / acetonitrile / 0.08 h / 0 °C
9: potassium carbonate / 1,4-dioxane / 0.08 h / 0 °C
10: dichloromethane / 1 h / 0 - 20 °C
With
hydrogenchloride; selenium(IV) oxide; N-Bromosuccinimide; sodium acetate; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; hydrazine hydrate; copper(II) sulfate; acetic acid; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: selenium(IV) oxide / 1,2-dimethoxyethane / 20 h / 130 °C
2: copper(II) sulfate / dichloromethane / 2 h / 20 °C
3: copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran; dichloromethane / 1 h / 0 - 20 °C
4: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 0 - 20 °C
5: triethylamine / dichloromethane / 0 °C
6: hydrazine hydrate / ethanol / 2 h / 20 °C
7: N-Bromosuccinimide / acetonitrile / 0.08 h / 0 °C
8: potassium carbonate / 1,4-dioxane / 0.08 h / 0 °C
9: dichloromethane / 1 h / 0 - 20 °C
With
hydrogenchloride; selenium(IV) oxide; N-Bromosuccinimide; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; hydrazine hydrate; copper(II) sulfate; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; acetonitrile;
